comparing 1918 H1N1 with 2004 H5N1
Posted in: darrelrussell.com edit
08 Jan 2009
o : difference
- : not both known
A/Brevig Mission/1/1918(H1N1)
A/Viet Nam/1194/2004(H5N1)
nucleotides, 8 segments : PB2,PB1,PA,HA,NP,NA,M,NS
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............o..................................... .o........................................o....... ..............o.....o..o..o..o.................... o......o....o..o..o...o.............---------------o..o.....o.......................o..o..o......... ......................................o..o.....o.. ..o............o..o........o.o.......o.......o.... .............o......o....o..o...........o..o...... ..o.....o..o.....o..o..o.....o........o........... ...........o...................o....o............. ................................o........o........ .............o....o.....o.........o............... o...........................o..................... ..o...o.............o.........o....o..o.....o..o.. o..o..o..o.....o.....................o............ ..............o.o.....................-- compare A/Brevig Mission/1/1918(H1N1) with A/Viet Nam/1194/2004(H5N1) nucleotide-codons, 8 segments: PB2,PB1,PA,HA,NP,NA,M,NS (multiple encodings in PB1,M,NS ignored) . : match * : difference - : not both available first base in codon only: ========================= ......oo.......................... .........................o........................ ...o................o........o.................... .o.......o................................o.....o. ..............o................................... ..............................................o... .................................................. .................................o............o..o ..............................o...........o....... o............................o..........o......... ............................o..................... ....o......o....................o................. ..............o....o.............................. .................................................. ..........o....................................... ..........................- .................................. .................................................. ............................o....o..............o. 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.................................................. .........o...o.................................... ....o........o.................................... ................................................o. .................................................. .................................................. .......................................o.......... .................................................. .................................................. ........................o......................... ......................................o........... ................o................................. .................................................. .................................................. .o................................................ .........-- .............o.................................... ...o.............................................. ............o...................................o. ...........................o...................... 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..........................o......................o ....o..............................o.............. .................................................. .................................................. ................................o................. ............o..................................... ......o...............o...o....................... .................................................. ......................o........o.............----- ................o..o..o.....o.........o....--------------------ooooo.....oooooooo..o.o........o...o. ....o............................................. ....o................................oo........... ........................................o......... ..o..o.o.....o..o..o..............o.ooo........... ......o...o................................o.o.... .o.o...........o.......................o.......... .................o...........o...o................ ...............o...-- ..............o...........o....................... .................................................. o...................o............................. ...............o.o................................ ....o.o................o.....o.o.o................ ..-- ...............o...o.....o.o..o................... .............o.o...........o...................-- ...............................................o.. ...................o....o....-----................ .................o........o....................... ....................o......o................o..o.. ....o.o.o..o....o.........o...-- .............o.......o.........................o.. ....o....o........................................ ..............o......-- most mutations are "synonymous" at 3rd base, they don't change the biological properties of the virus. All genes except HA (H1->H5) are still similar to those of 1918. There is a 20 amino-acid = 60 nucleotidedeletion now in NA and a 5 amino-acid=15 nucleotide deletion in NS. |
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